Article

Decoding directional genetic dependencies through orthogonal CRISPR/Cas screens

2017-03-25

Abstract excerpt

<h4>Summary</h4> Genetic interaction studies are a powerful approach to identify functional interactions between genes. This approach can reveal networks of regulatory hubs and connect uncharacterised genes to well-studied pathways. However, this approach has previously been limited to simple gene inactivation studies. Here, we present an orthogonal CRISPR/Cas-mediated genetic interaction approach that allows the...

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Literature Corpus work: 5354e9b9-664d-5757-b5bc-437a1849f6a4
DOI: 10.1101/120170

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