Article

Blood-brain barrier dysfunction promotes astrocyte senescence through albumin-induced TGFβ signaling activation

2022-04-28

Abstract excerpt

Blood-brain barrier dysfunction (BBBD) and accumulation of senescent astrocytes occur during brain aging and contribute to neuroinflammation and disease. Here, we explored the relationship between these two age-related events, hypothesizing that chronic hippocampal exposure to the blood-borne protein serum albumin could induce stress-induced premature senescence (SIPS) in astrocytes via transforming growth factor...

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Identifiers and source

Literature Corpus work: 534837a0-5966-514a-8b8e-79f79a27ff1a
DOI: 10.1101/2022.04.25.489438

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