Article

Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

2026-02-12

Abstract excerpt

One of the defining phenotypes of a senescent cell is the senescence-associated secretory phenotype (SASP), which can propagate senescence in neighboring cells both in vitro and in vivo . Importantly, this paracrine spreading of senescence can act in a cell non-autonomous manner, influencing neighboring cell populations and contributing to immune cell recruitment. As cellular senescence has recently been linked...

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Literature Corpus work: 8f7f09e7-72b7-517f-a6b0-668b7861724b
DOI: 10.64898/2026.02.10.705129

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