Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction

Abstract excerpt

Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying the transition from a young-and-healthy to aged-and-dysfunctional brain are not well understood. Here, we report breakdown of the vascular blood-brain barrier (BBB) in aging humans and rodents, which begins as early as middle age and progresses to the end of the lifespan. Gain-of-fun...

Topics

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• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Barrier Structure and Function Studies
• Blood-Brain Barrier
• Disease Models, Animal
• Mice, Transgenic
• Presenilin-1
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

0bfdb5bf-7e73-5d12-8233-4857435f5b3e

DOI

10.1101/537431