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Astrocyte senescence impairs synaptogenesis due to Thrombospondin-1 loss

2025-12-04

Abstract excerpt

Cellular senescence is an irreversible state linked to aging that involves molecular and functional alterations. The mammalian hippocampus, a key brain region for learning and memory, is highly vulnerable to damage in age-related neurodegenerative diseases, yet the role of cellular senescence in hippocampal aging remains underexplored. Here, we report an early onset of senescence signatures in hippocampal astrocyt...

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Literature Corpus work
2269aed5-3525-5a84-b882-82b749fe1d8d
DOI
10.64898/2025.12.02.691780
Open publication

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Astrocyte senescence impairs synaptogenesis due to Thrombospondin-1 lossDOI 10.64898/2025.12.02.691780
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