Article

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

2018-04-29

Abstract excerpt

Predicting the impact of cis -regulatory sequence on gene expression is a foundational challenge for biology. We combine polysome profiling of hundreds of thousands of randomized 5′ UTRs with deep learning to build a predictive model that relates human 5′ UTR sequence to translation. Together with a genetic algorithm, we use the model to engineer new 5′ UTRs that accurately target specified levels of ribosome loa...

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Literature Corpus work: 30a8c23d-9849-5cac-a3d6-945b3064c17c
DOI: 10.1101/310375

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