Article

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

2022-02-18

Abstract excerpt

mRNA regulatory sequences control gene expression at multiple levels including translation initiation and mRNA decay. The 5′ terminal sequences of mRNAs have unique regulatory potential because of their proximity to key post-transcriptional regulators. Here we have systematically probed the function of 5′ terminal sequences in gene expression in human cells. Using a library of reporter mRNAs initiating with all po...

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Literature Corpus work: 28b5e96b-8949-5731-ace9-7059b38a6862
DOI: 10.1101/2022.02.17.480814

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mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decayDOI 10.1101/2022.02.17.480814Read

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