Quantification of translation uncovers the functions of the alternative transcriptome

Abstract excerpt

At the center of the gene expression cascade, translation is fundamental in defining the fate of much of the transcribed genome. RNA sequencing enables the quantification of complex transcript mixtures, often detecting several splice isoforms of unknown functions for one gene. We have developed ORFquant , a new approach to annotate and quantify translation at the single open reading frame (ORF) level, using infor...

Topics

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• 5' Untranslated Regions
• Disease
• Gene Regulatory Networks
• Genome, Human
• Open Reading Frames
• Peptidase Inhibition and Analysis
• Protein Biosynthesis
• Protein Processing, Post-Translational

Identifiers and source

Literature Corpus work

4b54d55e-ae76-5d07-bd95-5c8d4ae20d6e

DOI

10.1101/608794