Article

Transcription factor activity profiling reveals the role of REST and LEF1 in the recovery from depression

2023-12-02

Abstract excerpt

Psychophysiological disorders chronically impair brain functions, often accompanied by dysregulation of multiple genes, suggesting a multifaceted etiology behind the symptoms. To explore transcription factors (TFs) involved in such transcriptomic changes, we analyzed TF-activity profiles (TFAPs) from the brains of mice experienced chronic stress, and revealed alteration in TF-activity correlating with their pathop...

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Literature Corpus work: 52f9a332-a35f-57e0-af42-c9532ac6272b
DOI: 10.1101/2023.11.30.569491

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