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Article

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

24 May 2016

Abstract excerpt

Major depressive disorder (MDD) is associated with a significantly elevated risk of developing serious medical illnesses such as cardiovascular disease, immune impairments, infection, dementia and premature death. Previous work has demonstrated immune dysregulation in subjects with MDD. Using genome-wide transcriptional profiling and promoter-based bioinformatic strategies, we assessed leukocyte transcription...

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PMID: 27219347
DOI: 10.1038/tp.2016.79

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