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NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy

18 Aug 2025

Abstract excerpt

Major depressive disorder (MDD) is characterized by persistent low mood and anhedonia. Mitochondrial dysfunction is linked to MDD, but the mechanisms are unclear. In this study, transcriptomic analysis of MDD patients' peripheral blood found three key genes: TFAM, SURF1, and NDUFB9. Single-cell transcriptomic analysis of the prefrontal cortex (PFC) in MDD patients identified seven cell types. Analysis showed...

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PMID: 40825941
DOI: 10.1038/s41398-025-03502-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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