Article
Transcriptomic analyses of humans and mice provide insights into depression.
Zoological research - 18 Nov 2020
Li Hui-Juan, Su Xi, Zhang Lu-Wen, Zhang Chu-Yi, Wang Lu, Li Wen-Qiang, Yang Yong-Feng, Lv Lu-Xian, Li Ming, Xiao Xiao
Abstract excerpt
Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder (MDD). In particular, transcriptomic analyses in brain regions engaged in cognitive and emotional processes, e.g., the dorsolateral prefrontal cortex (DLPFC), have provided essential insights. Based on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy...
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