Article
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.
Neuron - 1 Jun 2016
Bagot Rosemary C, Cates Hannah M, Purushothaman Immanuel, Lorsch Zachary S, Walker Deena M, Wang Junshi, Huang Xiaojie, Schlüter Oliver M, Maze Ian, Peña Catherine J, Heller Elizabeth A, Issler Orna, Wang Minghui, Song Won-Min, Stein Jason L, Liu Xiaochuan, Doyle Marie A, Scobie Kimberly N, Sun Hao Sheng, Neve Rachael L, Geschwind Daniel, Dong Yan, Shen Li, Zhang Bin, Nestler Eric J
Abstract excerpt
Depression is a complex, heterogeneous disorder and a leading contributor to the global burden of disease. Most previous research has focused on individual brain regions and genes contributing to depression. However, emerging evidence in humans and animal models suggests that dysregulated circuit function and gene expression across multiple brain regions drive depressive phenotypes. Here, we performed RNA...
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