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Article

Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice.

BMC neuroscience - 13 Nov 2013

Lisowski Pawel, Juszczak Grzegorz R, Goscik Joanna, Stankiewicz Adrian M, Wieczorek Marek, Zwierzchowski Lech, Swiergiel Artur H

Abstract excerpt

BACKGROUND: The effects of chronic treatment with tricyclic antidepressant (desipramine, DMI) on the hippocampal transcriptome in mice displaying high and low swim stress-induced analgesia (HA and LA lines) were studied. These mice displayed different depression-like behavioral responses to DMI: stress-sensitive HA animals responded to DMI, while LA animals did not. RESULTS: To investigate the effects of DMI...

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Identifiers

PMID: 24225037
DOI: 10.1186/1471-2202-14-144
PMCID: PMC3831054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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