Translational Identification of Transcriptional Signatures of Major Depression and Antidepressant Response

Abstract excerpt

Major depressive disorder (MDD) is a highly prevalent mental illness whose therapies management remains uncertain, with more than 20% of patients who do not achieve response to antidepressants. Therefore, identification of reliable biomarkers to predict response to treatment will greatly improve MDD patient medical care. Due to the inaccessibility and lack of brain tissues from living MDD patients to study...