Article

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human Cerebellum

2018-02-02

Abstract excerpt

BaxΔ2 is a pro-apoptotic protein originally discovered in colon cancer patients with high microsatellite instability. Unlike most pro-apoptotic Bax family members, BaxΔ2 mediates cell death through a non-mitochondrial caspase 8-dependent pathway. In the scope of analyzing the distribution of BaxΔ2 expression in human tissues, we examined a panel of human brain samples. Here, we report 4 cerebellar cases in which t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52d894b0-12db-5dd8-b546-bab2edb5f7bd
DOI: 10.1101/245910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human CerebellumDOI 10.1101/245910Read

Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues.Semantic proximity Read

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read

Tissue-specific vulnerability to apoptosis in Machado-Joseph diseaseSemantic proximity Read

Evaluation of polymorphic variants in apoptotic genes (Bcl-2 / Bax) and their roles in the development of myeloproliferative disorders (hematological malignancies) a case-controlled study.Semantic proximity Read

BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia.Semantic proximity Read

The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patientsSemantic proximity Read

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.Semantic proximity Read

Role ofbaxMutations in Apoptosis in Colorectal Cancers With Microsatellite InstabilitySemantic proximity Read

Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability.Semantic proximity Read

Genetic determinants of neuronal vulnerability to apoptosis.Semantic proximity Read

BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.Semantic proximity Read

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.Semantic proximity Read