Article

Tissue-specific vulnerability to apoptosis in Machado-Joseph disease

2023-04-09

Abstract excerpt

Machado-Joseph disease (MJD) is a dominant neurodegenerative disease caused by an expanded CAG repeat in the ATXN3 gene encoding the ataxin-3 protein. Several cellular processes, including transcription and apoptosis, are disrupted in MJD. To gain further insights into the extent of dysregulation of mitochondrial apoptosis in MJD, and to evaluate if expression alterations of specific apoptosis genes/proteins coul...

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Literature Corpus work: d96debd4-2f0a-560b-89e1-064dd5e81c6c
DOI: 10.1101/2023.04.09.536069

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