Article
BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.
Developmental neurobiology - 1 Apr 2007
Heitz S, Lutz Y, Rodeau J-L, Zanjani H, Gautheron V, Bombarde G, Richard F, Fuchs J-P, Vogel M W, Mariani J, Bailly Y
Abstract excerpt
Research efforts to deduce the function of the prion protein (PrPc) in knock-out mouse mutants have revealed that large deletions in the PrPc genome result in the ectopic neuronal expression of the prion-like protein Doppel (Dpl). In our analysis of one such line of mutant mice, Ngsk Prnp0/0 (NP0/0), we demonstrate that the ectopic expression of Dpl in brain neurons induces significant levels of cerebellar...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.