Article
BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia.
Journal of clinical immunology - 1 Jan 2010
Isaian Anna, Bogdanova Natalia V, Houshmand Masoud, Movahadi Masoud, Aghamohammadi Asghar, Agamohammadi Asghar, Rezaei Nima, Atarod Lida, Sadeghi-Shabestari Mahnaz, Tonekaboni Seyed Hasan, Chavoshzadeh Zahra, Hassani Seyed Mohammad Seyed, Mirfakhrai Reza, Cheraghi Taher, Kalantari Najmoddin, Ataei Mitra, Dork-Bousset Thilo, Sanati Mohammad Hossein
Abstract excerpt
INTRODUCTION: Ataxia telangiectasia (AT) is an autosomal recessive multisystem disorder characterized by variable immunodeficiency, progressive neurodegeneration, occulocutaneous telangiectasia, and an increased susceptibility to malignancies. This study was designed to study the role of proapoptotic BAK, BAX, and NBK/BIK genes in a group of patients with AT to elucidate the possible role of these genes in...
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