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Article

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.

The American journal of pathology - 1 Aug 2007

Dong Jiaxin, Li Aimin, Yamaguchi Naohiro, Sakaguchi Suehiro, Harris David A

Abstract excerpt

Doppel (Dpl) is a prion protein paralog that causes neurodegeneration when expressed ectopically in the brain. To investigate the cellular mechanism underlying this effect, we analyzed Dpl-expressing transgenic mice in which the gene for the proapoptotic protein Bax had been deleted. We found tha...

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Identifiers

PMID: 17569776
DOI: 10.2353/ajpath.2007.070262
PMCID: PMC1934519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17569776-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.PMID 17569776Read ↗

BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.Semantic proximity Read ↗

Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment.Semantic proximity Read ↗

Doppel induces autophagic stress in prion protein-deficient Purkinje cells.Semantic proximity Read ↗

Doppel-induced cerebellar degeneration in transgenic mice.Semantic proximity Read ↗

Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.Semantic proximity Read ↗

Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice.Semantic proximity Read ↗

Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein.Semantic proximity Read ↗

Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's DiseasesSemantic proximity Read ↗

Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.Semantic proximity Read ↗

Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion.Semantic proximity Read ↗

Bax‐like protein Drob‐1 protects neurons from expanded polyglutamine‐induced toxicity in DrosophilaSemantic proximity Read ↗

The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis.Semantic proximity Read ↗

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