Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

Blood - 15 Apr 1998

Meijerink J P, Mensink E J, Wang K, Sedlak T W, Slöetjes A W, de Witte T, Waksman G, Korsmeyer S J

Abstract excerpt

The BCL-2 gene family regulates the susceptibility to apoptotic cell death in many cell types during embryonic development and normal tissue homeostasis. Deregulated expression of anti-apoptotic BCL-2 can be a primary aberration that promotes malignancy and also confers resistance to chemotherapeutic agents. Recently, studies of Bax-deficient mice have indicated that the pro-apoptotic BAX molecule can function as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Hematologic Neoplasms
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Conformation

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9531611

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.PMID 9531611Read ↗

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.Semantic proximity Read ↗

Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance.Semantic proximity Read ↗

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugsSemantic proximity Read ↗

The mitochondrial anti-apoptotic dependencies of hematologic malignancies: from disease biology to advances in precision medicineSemantic proximity Read ↗

Mutation of BAX occurs infrequently in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas.Semantic proximity Read ↗

Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.Semantic proximity Read ↗

Bax mutations are an infrequent event in indolent lymphomas and in mantle cell lymphoma.Semantic proximity Read ↗

Evaluation of polymorphic variants in apoptotic genes (Bcl-2 / Bax) and their roles in the development of myeloproliferative disorders (hematological malignancies) a case-controlled study.Semantic proximity Read ↗

Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues.Semantic proximity Read ↗

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.Semantic proximity Read ↗

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemiaSemantic proximity Read ↗

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.