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Article

Hijacking the Chromatin Remodeling Machinery: Impact of<i>SWI/SNF</i>Perturbations in Cancer

21 Oct 2009

Abstract excerpt

There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical...

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PMID: 19843852
DOI: 10.1158/0008-5472.can-09-2166

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