Article
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases.
Cell reports. Medicine - 17 Oct 2023
Durfee Cameron, Temiz Nuri Alpay, Levin-Klein Rena, Argyris Prokopios P, Alsøe Lene, Carracedo Sergio, Alonso de la Vega Alicia, Proehl Joshua, Holzhauer Anna M, Seeman Zachary J, Liu Xingyu, Lin Yu-Hsiu T, Vogel Rachel I, Sotillo Rocio, Nilsen Hilde, Harris Reuben S
Abstract excerpt
The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many cancers. However, despite years of work, a causal relationship has yet to be established in vivo. Here, we report a murine model that expresses tumor-like levels of human APOBEC3B. Animals expressing full-body APOBEC3B appear to develop normally. However, adult males manifest infertility, and older animals of both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.