Article

Human APOBEC3B promotes tumor heterogeneity <i>in vivo</i> including signature mutations and metastases

2023-02-25

Abstract excerpt

<h4>SUMMARY</h4> The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many different cancers. Despite over 10 years of work, a causal relationship has yet to be established between APOBEC3B and any stage of carcinogenesis. Here we report a murine model that expresses tumor-like levels of human APOBEC3B after Cre-mediated recombination. Animals appear to develop normally wit...

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Literature Corpus work: a04af221-ce3b-5690-91c6-17e55720e326
DOI: 10.1101/2023.02.24.529970

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