APOE expression and secretion are modulated by mitochondrial dysfunction.

doi:10.7554/eLife.85779

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Article

APOE expression and secretion are modulated by mitochondrial dysfunction.

eLife - 12 May 2023

Wynne Meghan E, Ogunbona Oluwaseun, Lane Alicia R, Gokhale Avanti, Zlatic Stephanie A, Xu Chongchong, Wen Zhexing, Duong Duc M, Rayaprolu Sruti, Ivanova Anna, Ortlund Eric A, Dammer Eric B, Seyfried Nicholas T, Roberts Blaine R, Crocker Amanda, Shanbhag Vinit, Petris Michael, Senoo Nanami, Kandasamy Selvaraju, Claypool Steven Michael, Barrientos Antoni, Wingo Aliza, Wingo Thomas S, Rangaraju Srikant, Levey Allan I, Werner Erica, Faundez Victor

Abstract excerpt

Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive than previously appreciated, as both genetic and pharmacological disruption of the electron transport chain caused upregulation of the Alzheimer's disease risk factor...

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PMID: 37171075
DOI: 10.7554/eLife.85779
PMCID: PMC10231934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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