Article

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

2022-05-11

Abstract excerpt

Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive than previously appreciated, as both genetic and pharmacological disruption of the electron transport chain caused upregulation of the Alzheimer’s disease risk factor apo...

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Literature Corpus work: 9aa8b7ad-67c6-57f1-8390-cb933a9bb5af
DOI: 10.1101/2022.05.11.491499

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