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Article

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord

2024-11-14

Abstract excerpt

Development of therapeutic approaches that target specific microglia responses in amyotrophic lateral sclerosis (ALS) is crucial due to the involvement of microglia in ALS progression. Our study identifies the predominant microglia subset in human ALS primary motor cortex and spinal cord as an undifferentiated phenotype with dysregulated respiratory electron transport. Moreover, we find that the interferon respons...

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Identifiers and source

Literature Corpus work
96561f45-132f-5d27-81d5-da12bf4b6f5b
DOI
10.1101/2024.11.12.623183
Open publication

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Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cordDOI 10.1101/2024.11.12.623183
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