Article

Aquaporin-4 polymorphisms modify the penetrance of Parkinson’s disease in <i>leucine-rich repeat kinase 2</i> carriers

2025-10-07

Abstract excerpt

<h4>Background</h4> Pathogenic mutations in the leucine-rich repeat kinase-2 ( LRRK2 ) gene are the most common cause of familial Parkinson’s disease (PD). LRRK2 shows incomplete penetrance, yet the biological factors influencing disease expression remain unknown. <h4>Objectives</h4> To investigate whether genetic variants in aquaporin-4 ( AQP4 ), key in glymphatic system functioning, are associated with the pen...

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Literature Corpus work: ea73da7c-8d12-5180-b0ed-92f44e2bc31b
DOI: 10.1101/2025.10.04.25337325

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