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Article

Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.

Brain : a journal of neurology - 3 Jun 2024

Kmiecik Matthew J, Micheletti Steven, Coker Daniella, Heilbron Karl, Shi Jingchunzi, Stagaman Keaton, Filshtein Sonmez Teresa, Fontanillas Pierre, Shringarpure Suyash, Wetzel Madeleine, Rowbotham Helen M, Cannon Paul, Shelton Janie F, Hinds David A, Tung Joyce Y, Holmes Michael V, Aslibekyan Stella, Norcliffe-Kaufmann Lucy

Abstract excerpt

The LRRK2 G2019S variant is the most common cause of monogenic Parkinson's disease (PD); however, questions remain regarding the penetrance, clinical phenotype and natural history of carriers. We performed a 3.5-year prospective longitudinal online study in a large number of 1286 genotyped LRRK2 G2019S carriers and 109 154 controls, with and without PD, recruited from the 23andMe Research Cohort. We collected...

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Identifiers

PMID: 38804604
DOI: 10.1093/brain/awae073
PMCID: PMC11146432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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