Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

doi:10.1016/S1474-4422(08)70117-0

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Article

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

The Lancet. Neurology - 1 Jul 2008

Healy Daniel G, Falchi Mario, O'Sullivan Sean S, Bonifati Vincenzo, Durr Alexandra, Bressman Susan, Brice Alexis, Aasly Jan, Zabetian Cyrus P, Goldwurm Stefano, Ferreira Joaquim J, Tolosa Eduardo, Kay Denise M, Klein Christine, Williams David R, Marras Connie, Lang Anthony E, Wszolek Zbigniew K, Berciano Jose, Schapira Anthony H V, Lynch Timothy, Bhatia Kailash P, Gasser Thomas, Lees Andrew J, Wood Nicholas W

Abstract excerpt

BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to answer three key clinical questions: can LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit or are at risk of...

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PMID: 18539534
DOI: 10.1016/S1474-4422(08)70117-0
PMCID: PMC2832754

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