Article
Penetrance of Parkinson disease LRRK2 G2385R-associated variant in the Chinese population.
European journal of neurology - 1 Sept 2022
Wang Pei, Cui Peijing, Luo Qi, Chen Jie, Tang Huidong, Zhang Lina, Chen Shengdi, Ma Jianfang
Abstract excerpt
BACKGROUND AND PURPOSE: Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) variants for Parkinson disease (PD) vary widely. G2385R is one of the most common LRRK2 variants in Asian populations, and its penetrance is currently unknown. We aimed to estimate the penetrance of G2385R in the Chinese population. METHODS: The G2385R variant was tested by Sanger sequencing in 6386 participants older than...
Topics
- China
- Female
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Mutation
- Parkinson Disease
- Penetrance
- Protein Serine-Threonine Kinases