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Article

CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation.

Nucleic acids research - 20 Aug 2020

Tellier Michael, Zaborowska Justyna, Caizzi Livia, Mohammad Eusra, Velychko Taras, Schwalb Björn, Ferrer-Vicens Ivan, Blears Daniel, Nojima Takayuki, Cramer Patrick, Murphy Shona

Abstract excerpt

Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of DNA damage response genes remain unclear. Here, we have used TT-seq and mNET-seq to monitor the direct effects of rapid CDK12 inhibition on transcription activity and CTD phosphorylation in human cells. CDK12 inhibition causes a genome-wide...

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Identifiers

PMID: 32805052
DOI: 10.1093/nar/gkaa514
PMCID: PMC7641311

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