Article

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II

2020-06-15

Abstract excerpt

Reversible phosphorylation of Pol II and accessory factors helps order the transcription cycle. Here we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize to 3’ and 5’ ends of genes, respectively, and have overlapping but distinct specificities for Cdk9-dependent phosphor...

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Literature Corpus work: 438d21b0-289f-51aa-bf79-100dac0790da
DOI: 10.1101/2020.06.14.150847

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