Article
Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation.
The Journal of biological chemistry - 3 Mar 2000
Schang L M, Hwang G J, Dynlacht B D, Speicher D W, Bantly A, Schaffer P A, Shilatifard A, Ge H, Shiekhattar R
Abstract excerpt
The activity of cyclin-dependent protein kinases (cdks) is physiologically regulated by phosphorylation, association with the specific cyclin subunits, and repression by specific cdk inhibitors. All three physiological regulatory mechanisms are specific for one or more cdks, but none is known to be substrate specific. In contrast, synthetic cdk peptide inhibitors that specifically inhibit cdk phosphorylation of...
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