Article

A Cdk9-PP1 kinase-phosphatase switch regulates the elongation-termination transition of RNA polymerase II

2017-09-19

Abstract excerpt

The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to ensure proper mRNA maturation and prevent interference between neighboring genes 1 . Pol II slowing downstream of the cleavage and polyadenylation signal (CPS) leads to recruitment of cleavage and polyadenylation factors and termination 2 , but how this chain of events is initiated remains unclear. In a chemical-genetic screen...

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Literature Corpus work: 63bdb53c-012e-5c84-929d-c849704f7ba0
DOI: 10.1101/190488

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