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Article

CDK9 as an Appealing Target for Therapeutic Interventions

29 Oct 2018

Abstract excerpt

Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. In this...

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PMID: 30362418
DOI: 10.2174/1389450119666181026152221

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