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Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylation

1 May 2020

Abstract excerpt

Cyclin-dependent kinases (CDKs) play critical roles in cell cycle progression and gene expression regulation. In human cancer, transcription-associated CDKs can activate oncogenic gene expression programs, whereas cell cycle-regulatory CDKs mainly induce uncontrolled proliferation. Cyclin-dependent kinase 12 (CDK12) belongs to the CDK family of serine/threonine kinases and has been recently found to have multiple...

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PMID: 32451425
DOI: 10.1038/s12276-020-0442-9

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