Article

Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice

2024-02-29

Abstract excerpt

<title>Abstract</title> <p> In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([ <sup>18</sup> F]VAT) in vivo in humans, and genetically targeted cholinergic markers in mice, we evaluated whether changes to the cholinergic system were an early feature of age-related cognitive declin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52838056-0715-59fb-8aaf-60cdf2d07c4e
DOI: 10.21203/rs.3.rs-3851086/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and miceDOI 10.21203/rs.3.rs-3851086/v2Read

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.Semantic proximity Read

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentSemantic proximity Read

Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.Semantic proximity Read

Entorhinal cholecystokinin in Alzheimer’s disease: its earliest vulnerability and rescue effects across different disease stagesSemantic proximity Read

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model miceSemantic proximity Read

Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s diseaseSemantic proximity Read

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype.Semantic proximity Read

Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging miceSemantic proximity Read

Cholinergic synaptic plasticity shapes resilience and vulnerability to tauSemantic proximity Read

Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuitsSemantic proximity Read

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer’s disease pathologySemantic proximity Read

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model miceSemantic proximity Read