Article

Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s disease

2025-06-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In mild cognitive impairment and dementia due to Alzheimer’s disease (AD), postmortem and in vivo neuroimaging studies have demonstrated significant neuronal loss in the basal forebrain cholinergic system (BFCS), which provides the primary cholinergic input to the cerebral cortex. Within this region, atrophy is most prominent in the nucleus basalis of Meynert (nbM), a group...

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Literature Corpus work: 928bbee1-9fe6-5e94-8c22-ab0449b9c4eb
DOI: 10.1101/2025.05.28.656557

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