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Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging mice

2025-07-14

Abstract excerpt

<h4>SUMMARY</h4> In humans, decreases in rapid eye movement sleep (REMS) strongly predict Alzheimer’s disease (AD), alongside early degeneration of basal forebrain cholinergic neurons. We examined how β-amyloid pathology gradually erodes mouse cholinergic neurons. The familial App NL-G-F allele was selectively expressed in medial septal (MS) cholinergic neurons of both sexes and compared with mice with global Ap...

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Literature Corpus work
3f0d68a5-4321-505f-a9c0-6b7b465286af
DOI
10.1101/2025.07.09.663930
Open publication

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Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging miceDOI 10.1101/2025.07.09.663930
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