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Article

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2013

Lane Roger M, He Yunsheng

Abstract excerpt

Retrospective data are presented to support a spectrum of early Alzheimer's disease (AD) along a continuum defined by gender and genotype. The putative neurodegenerative mechanisms driving distinct phenotypes at each end of the spectrum are glial hypoactivity associated with early failure of synaptic cholinergic neurotransmission and glial overactivation associated with loss of neural network connectivity due to...

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PMID: 22402324
DOI: 10.1016/j.jalz.2010.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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