Article

Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits

2023-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The disconnection of neuronal circuits through synaptic loss is presumed to be a major driver of age-related cognitive decline. Age-related cognitive decline is heterogeneous, yet whether genetic mechanisms differentiate successful from unsuccessful cognitive decline through synaptic structural mechanisms remains unknown. Previous work using rodent and primate models leveraged various techniques...

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Literature Corpus work: 480893a8-c2ab-5b80-b58b-7fe2cc68aac0
DOI: 10.1101/2023.07.27.550869

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