Article

Entorhinal cholecystokinin in Alzheimer’s disease: its earliest vulnerability and rescue effects across different disease stages

2025-10-29

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. The entorhinal cortex (Ent) is among the earliest affected regions, and its neuropeptide cholecystokinin (CCK) supports neocortical-associated memory. Although our previous work demonstrated that CCK treatment rescues cognition and neuroplasticity in aged AD mice, the correlations am...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edd27dc6-b7b4-5151-b25d-9c398b797fa3
DOI: 10.21203/rs.3.rs-7630814/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Entorhinal cholecystokinin in Alzheimer’s disease: its earliest vulnerability and rescue effects across different disease stagesDOI 10.21203/rs.3.rs-7630814/v1Read

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Semantic proximity Read

Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.Semantic proximity Read

Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Revealing Notch-dependencies in synaptic targets associated with Alzheimer’s diseaseSemantic proximity Read

Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and miceSemantic proximity Read

ABCA7-dependent Neuropeptide-Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s diseaseSemantic proximity Read

Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In MiceSemantic proximity Read

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Semantic proximity Read

ApoE4 attenuates cortical neuronal activity and impairs memory in young apoE4 ratsSemantic proximity Read

Decoding the underlying neural activity of neurodegeneration in Alzheimer’s DiseaseSemantic proximity Read

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s mouse modelSemantic proximity Read

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s diseaseSemantic proximity Read