Article

Cholinergic synaptic plasticity shapes resilience and vulnerability to tau

2025-05-28

Abstract excerpt

Synaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Yet due to their plasticity, synapses may also adapt to early AD pathology. Here, we demonstrate that cholinergic neurons mount a presynaptic response to tau pathology in the living human brain. Using multi-tracer positron emission tomography in cognitively normal older adults at risk for AD, we observe that cholinergic neurons increase presynaptic ve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29408af4-a999-5e46-93c8-637c4f68b19f
DOI: 10.1101/2025.05.27.656174

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cholinergic synaptic plasticity shapes resilience and vulnerability to tauDOI 10.1101/2025.05.27.656174Read

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease miceSemantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer’s DiseaseSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity Read

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s diseaseSemantic proximity Read

Altered Synapse Stability in the Early Stages of TauopathySemantic proximity Read

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory LossSemantic proximity Read

Structural and Synaptic Dysregulation Drives Network Vulnerability in APOE4 Human Neuronal NetworksSemantic proximity Read

Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in DiseaseSemantic proximity Read

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimer’s Disease with PsychosisSemantic proximity Read

NPTX2-Centered Cognitive Resilience Mechanisms in the Context of AD PathologySemantic proximity Read