Article

Injection of antibodies against immunodominant epitopes tunes germinal centres to generate broadly neutralizing antibodies

2018-12-19

Abstract excerpt

The development of broadly neutralizing antibodies is critical for the control of many life-threatening viral infections like HIV, influenza, or hepatitis. Elite neutralizers are generated by natural germinal centre (GC) reactions in a very small subset of patients. The best strategy of how to promote the generation of broadly neutralizing antibodies is not known. Here, computer simulations of GC reactions are use...

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Literature Corpus work: 522093dd-3827-5b4f-ba15-5e7261619424
DOI: 10.1101/501247

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