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Article

Exceptional Antibodies Produced by Successive Immunizations.

PLoS biology - 1 Dec 2015

Gearhart Patricia J, Castiblanco Diana P, Russell Knode Lisa M

Abstract excerpt

Antibodies stand between us and pathogens. Viruses mutate quickly to avoid detection, and antibodies mutate at similar rates to hunt them down. This death spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences. Here, we explore how B lymphocytes stay in the race by expressing activation-induced deaminase, which unleashes a tsunami of mutations in the immunoglobulin loci....

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Source

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Identifiers

PMID: 26641938
DOI: 10.1371/journal.pbio.1002321
PMCID: PMC4671562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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