Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

Abstract excerpt

Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. Through the GC lifespan, interclonal competition between B cells leads to increased affinity of the B cell receptors for antigens accompanied by a loss of clonal diversity, although the mechanisms...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Cell Function and Interaction
• Share to Monoclonal and Polyclonal Antibodies Research
• Share to T-cell and B-cell Immunology