Article
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science (New York, N.Y.) - 13 Apr 2018
Burnett Deborah L, Langley David B, Schofield Peter, Hermes Jana R, Chan Tyani D, Jackson Jennifer, Bourne Katherine, Reed Joanne H, Patterson Kate, Porebski Benjamin T, Brink Robert, Christ Daniel, Goodnow Christopher C
Abstract excerpt
Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse model, we generated B cells displaying an antibody that cross-reacts with two related protein antigens expressed on self versus foreign cells. B cell anergy was imposed by self antigen but reversed upon challenge with high-density foreign antigen, leading...
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