Article

Prenatal<i>BRCA1</i>epimutations contribute significantly to triple-negative breast cancer development

2023-05-16

Abstract excerpt

<h4>Background</h4> Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is unknown. <h4>Methods</h4> To address this question, we analyzed BRCA1 methylation status in breast cancer tissue and matched white blood cells (WBC) from 411 patients with primary breast canc...

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Literature Corpus work: 521c6154-01be-52ff-b2df-b49d0b41911d
DOI: 10.1101/2023.05.14.23289949

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