Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2011

Wong Ee Ming, Southey Melissa C, Fox Stephen B, Brown Melissa A, Dowty James G, Jenkins Mark A, Giles Graham G, Hopper John L, Dobrovic Alexander

Abstract excerpt

Women carrying germline mutations in BRCA1 are at a substantially elevated risk of breast cancer and their tumors typically have distinctive morphologic features. We hypothesized that constitutional methylation of the BRCA1 promoter region could give rise to such breast cancers in women. We selec...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Australia
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Case-Control Studies

Share to DNA Methylation

Share to DNA, Neoplasm

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20978112
DOI: 10.1158/1940-6207.CAPR-10-0212
PMCID: PMC4030007

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20978112-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.PMID 20978112Read ↗

Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women.Semantic proximity Read ↗

BRCA1 promoter methylation in peripheral blood is associated with the risk of triple‐negative breast cancerSemantic proximity Read ↗

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype.Semantic proximity Read ↗

BRCA1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with BRCA1 promoter methylation.Semantic proximity Read ↗

BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.Semantic proximity Read ↗

Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry.Semantic proximity Read ↗

Peripheral blood DNA methylation analysis reveals epigenetic marks associated with hereditary breast and ovarian cancer riskSemantic proximity Read ↗

Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms.Semantic proximity Read ↗

Blood cells of BRCA1 mutation and epimutation carries appear to acquire specific epigenetic signaturesSemantic proximity Read ↗

BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylationSemantic proximity Read ↗

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.Semantic proximity Read ↗

Aberrant promoter methylation of HIN-1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.